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Rosetta Stone V3 – Dutch (L1, L2, L3) (ISO). Get Rosetta Stone Tutorial, User Guide, and support for Rosetta.. Level 2 Language (ENGLISH/IRISH. Rosetta Stone V3 – English (British) (L1, L2, L3) (ISO). Get free Rosetta Stone Trial for.
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Intraperitoneal self-administration of methamphetamine (MA) is facilitated when the meso-limbic dopamine (DA) system is enhanced by the activity of the nucleus accumbens (NAc) projections to the ventral pallidum (VP). The VP is further reciprocally connected with the thalamus (TH) and, to a lesser extent, with the striatum (STR). These connections may in part be involved in the accumbal facilitation of self-administration of MA. Here we investigated the role of the VP, TH, NAc and STR in the self-administration of MA. To do so, we performed an electrolytic lesion of the VP or STR or a microinjection of an excitatory amino acid (EAA) into the NAc. The systemic administration of EAA had no effect on MA self-administration in rats. The VP lesion had no effect on MA self-administration, but the STR lesion attenuated MA self-administration. These results suggest that the NAc is an important relay nucleus of the thalamic input to the VP which modulates MA self-administration. However, the medial striatal projection to the VP, which may be related to
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