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The performance of clinically relevant metallic implants is strongly influenced by their hemocompatibility. Uncoated hydroxyapatite (HA) and coatings of different compositions (e.g. plasma spray, laser vaporization, hot isostatic pressing, and bioglass) were tested regarding their influence on coagulation parameters and complement activation in vitro and on some hemostasis parameters in vivo. No interference of HA with the coagulation system was found in vitro or in vivo. The test systems showed no hypersensitivity reactions to HA. Therefore, coated and uncoated HA were not cytotoxic. In the presence of complement, as well as in vivo, coated HA and uncoated HA showed no significant influence on coagulation parameters. The same applies to thromboplastin activation. Bioglass coatings were significantly more hemotoxic in vitro as compared to both uncoated and coated HA. Differences between coating and uncoating were less pronounced in vivo. Our results indicate that coatings of HA and bioglass can be regarded as safe for implantation. Only coating with bioglass may be slightly more hazardous than uncoated HA implants and appears not to be a problem in biodegradable, implantable stents.C’è una grande differenza tra i centri di smistamento di lavoro e di ricerca nei più importanti centri di impresa e costruzione pubblica. Lo afferma in un rapporto l
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